Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection† †Electronic Supplementary Information (ESI) available: Detailed experimental methods, synthesis and characterization of α-DTPEBBTD-Cx and β-DTPEBBTD-Cx, cell imaging, in vitro and in vivo toxicities, biodistribution, blood circulation, and hematoxylin and eosin (H&E) histological analyses. See DOI: 10.1039/c6sc04384d Click here for additional data file.

Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection.

Near infrared (NIR) fluorescence imaging (700-900 nm) is a promising technology in preclinical and clinical tumor diagnosis and therapy. The availability of excellent NIR fluorescent contrast agents is still the main barrier to implementing this technology. Herein, we report the design and synthesis of two series of NIR fluorescent molecules with long wavelength excitation and aggregation-induc...

An unprecedented amplification of near-infrared emission in a Bodipy derived π-system by stress or gelation† †Electronic supplementary information (ESI) available: Experimental details, synthesis procedures and characterization data of the compounds, and additional figures. CCDC 1523313. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01696d Click here for additional data file. Click here for additional data file.

An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles† †Electronic supplementary information (ESI) available: Detailed information on the synthetic routes to various ligands, characterization data, additional figures, schemes, tables and general experiment procedures are provided. See DOI: 10.1039/c5sc01850a Click here for additional data file.

Near-infrared (NIR) fluorescence imaging is promising due to the high penetration depths and minimal levels of autofluorescence in living systems. However, it suffers from low fluorescent quantum yield, and metal-enhanced fluorescence (MEF) is considered to be a promising technique to overcome this. Stimuli-responsive NIR fluorescence enhancement shows remarkable potential for applications in m...

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05712h Click here for additional data file.

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00251c Click here for additional data file.